Carbon-14 radiosynthesis of the benzofuran derivative and β-amyloid plaque neuroimaging positron emission tomography radioligand AZD4694.

Abstract

In support of a metabolite study, the β-amyloid plaque neuroimaging positron-emission tomography radioligand AZD4694 was labeled with carbon-14 in 10 radiosynthetic steps starting from radiolabeled carbon dioxide. [(14)C]AZD4694 was labeled in the benzofuran heterocycle with a specific activity of 2.1 GBq/mmol and with a radiochemical purity of >99%. The described synthesis constitutes a general method to carbon-14-labeled substituted benzofurans.

• Authors: Johan Sandell
• Journal: Journal of labelled compounds & radiopharmaceuticals (J Labelled Comp Radiopharm) Vol. 56 Issue 6 Pg. 321-4 (May 30 2013) ISSN: 1099-1344 [Electronic] England
• PMID: 24285412 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 John Wiley & Sons, Ltd.

Chemical References

• AZD4694
• Benzofurans
• Carbon Radioisotopes
• Hydrocarbons, Fluorinated
• Radiopharmaceuticals

Topics

• Benzofurans (chemical synthesis)
• Carbon Radioisotopes (chemistry)
• Hydrocarbons, Fluorinated (chemical synthesis)
• Positron-Emission Tomography (methods)
• Radiopharmaceuticals (chemical synthesis)