Pharmacokinetic comparisons of berberine and palmatine in normal and metabolic syndrome rats.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

San-Huang formula is a popular traditional Chinese medicine (TCM) preparation to replenish Qi, resolve phlegm, dissipate blood stasis, and therapy metabolic syndrome in China. Metabolic syndrome, which is accompanied by Qi and blood stasis, mainly arises from spleen deficiency in essence. There is limited information available for differences of pharmacokinetic properties of San-Huang formula between normal and metabolic syndrome rats. The present study was conducted to compare the pharmacokinetics of berberine as well as palmatine in normal and metabolic syndrome rats following oral administration of San-Huang formula extract.

MATERIALS AND METHODS:

The animals were orally administered with San-Huang formula extract with the equivalent dose of 60.4 and 12.5mg/kg for berberine and palmatine, respectively. The blood samples were collected according to the time schedule. The concentrations of berberine and palmatine in rat plasma were determined by LC-ESI/MS. Various pharmacokinetic parameters were estimated from the plasma concentration versus time data using non-compartmental methods.

RESULTS:

It was found that AUC0-t, Cmax, Vd and CL of berberine and palmatine in metabolic syndrome rats were significantly different (P<0.05) from normal rats.

CONCLUSIONS:

The results indicated that berberine and palmatine have higher uptake and slower elimination in the rats with metabolic syndrome, which suggests that the rate and extent of drug metabolism were altered in metabolic syndrome rats.

• Authors: Qing-Feng Liu, Xiao-Jin Shi, Zhong-Dong Li, Ming-kang Zhong, Zheng Jiao, Bin Wang
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 151 Issue 1 Pg. 287-91 ( 2014) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 24269776 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Berberine Alkaloids
• Drugs, Chinese Herbal
• San-Huang
• Berberine
• palmatine

Topics

• Administration, Oral
• Animals
• Area Under Curve
• Berberine (pharmacokinetics)
• Berberine Alkaloids (pharmacokinetics)
• Drugs, Chinese Herbal (chemistry)
• Half-Life
• Male
• Metabolic Syndrome (metabolism)
• Molecular Structure
• Random Allocation
• Rats