Evaluation of CXCL8, CXCL10, CXCL11, CXCL12 and CXCL13 in serum and cerebrospinal fluid of patients with neuroborreliosis.

Abstract

PURPOSE:

Knowledge of the role of chemokines in the inflammation during neuroborreliosis (NB) is limited. We evaluated the pre- and post-treatment concentration of CXCL8, CXCL10, CXCL11, CXCL12, and CXCL13 in serum (s) and cerebrospinal fluid (csf) in patients with NB.

RESULTS:

There was a statistically significant increase in pre-treatment s CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 and csf CXCL8, CXCL11, CXCL12, CXCL13 in patients with early form of NB. CXCL8, CXCL11, CXCL12 and CXCL13 increase was the highest in csf. After treatment, a significant decrease in csf chemokine levels (except CXCL10) and s levels (except CXCL11) was observed.

CONCLUSIONS:

CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 are involved in the pathomechanism of NB but their role is different in s and csf. CXCL13 seems to be a good biomarker for NB. In early NB, it may facilitate the diagnosis and monitoring of therapy. However tick-borne encephalitis needs to be excluded as it also increases chemokine concentration. Decrease in all examined chemokines in s and csf after treatment suggests that chemokines may be useful in monitoring response to NB therapy.

• Authors: Anna Moniuszko, Piotr Czupryna, Sławomir Pancewicz, Krzysztof Rutkowski, Olga Zajkowska, Renata Swierzbińska, Sambor Grygorczuk, Maciej Kondrusik, Piotr Owłasiuk, Joanna Zajkowska
• Journal: Immunology letters (Immunol Lett) 2014 Jan-Feb Vol. 157 Issue 1-2 Pg. 45-50 ISSN: 1879-0542 [Electronic] Netherlands
• PMID: 24239846 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Chemokine CXCL10
• Chemokine CXCL11
• Chemokine CXCL12
• Chemokine CXCL13
• Chemokines, CXC
• Interleukin-8

Topics

• Adult
• Aged
• Aged, 80 and over
• Chemokine CXCL10
• Chemokine CXCL11
• Chemokine CXCL12
• Chemokine CXCL13
• Chemokines, CXC (blood, cerebrospinal fluid)
• Female
• Humans
• Interleukin-8
• Lyme Neuroborreliosis (blood, cerebrospinal fluid)
• Male
• Middle Aged
• ROC Curve
• Reference Values