Chronic migraine in women is associated with insulin resistance: a cross-sectional study.

Abstract

BACKGROUND AND PURPOSE:

Migraine is a common neurological disorder. It can be divided into episodic migraine (EM) and chronic migraine (CM), based on headache frequency. Some studies have shown that insulin sensitivity is impaired in migraine; moreover, hypertension, diabetes and obesity are common in patients with CM. The aim of this study was to assess serum glucose, insulin levels and insulin resistance (IR) in a sample of episodic migraineurs, chronic migraineurs and non-pain healthy controls.

METHODS:

Eighty-three women with EM, 83 with CM and 83 healthy controls were recruited. Headache was diagnosed according to the latest International Classification of Headache Disorders 2 criteria. Waist circumference, body mass index (BMI) and blood pressure were measured. Checked metabolic parameters included fasting glucose, the 2 h 75 g oral glucose tolerance test (2 h OGTT), serum HbA1c, blood lipid profile, C-reactive protein and prolactin. The homeostasis model assessment formula was used to calculate IR.

RESULTS:

A significant prevalence of IR in CM was observed (P = 0.002). No significant associations were found with fasting glycaemia, the 2 h OGTT, HbA1c, blood lipid profile, C-reactive protein, prolactin and waist circumference. Obesity (BMI >30 kg/m(2)) was associated with an increased risk of CM [odds ratio (OR) 2.4]. When the outcome of interest was the association between IR and obesity, the OR was significantly increased compared with IR alone (OR = 13.2).

CONCLUSION:

This may suggest that CM is associated with IR status, particularly when it is in partnership with obesity.

• Authors: A Fava, D Pirritano, D Consoli, M Plastino, F Casalinuovo, S Cristofaro, C Colica, C Ermio, M De Bartolo, C Opipari, R Lanzo, A Consoli, D Bosco
• Journal: European journal of neurology (Eur J Neurol) Vol. 21 Issue 2 Pg. 267-72 (Feb 2014) ISSN: 1468-1331 [Electronic] England
• PMID: 24238370 (Publication Type: Journal Article)
• Copyright: © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.

Chemical References

• Blood Glucose

Topics

• Adult
• Blood Glucose (metabolism)
• Body Mass Index
• Cross-Sectional Studies
• Female
• Glucose Tolerance Test
• Humans
• Insulin Resistance (physiology)
• Middle Aged
• Migraine Disorders (complications, physiopathology)
• Obesity (complications, physiopathology)
• Waist Circumference