This study investigated the prevalence and determinants of
hyperuricemia in Chinese
type 2 diabetes mellitus (T2DM) patients with
central obesity. A multicentric hospital-based cross-sectional study was carried out in Guangdong Province between August 2011 and March 2012. At each hospital, Chinese T2DM patients with
central obesity who were aged over 20 years, whose serum
uric acid levels were measured, and who had lived in Guangdong Province for >=1 year, were recruited.
Hyperuricemia was defined as serum
uric acid >420 μmol/L in men and >360 μmol/L in women. Binary logistic regression was used to assess associated risk factors for hyperu-ricemia. A total of 2,917 T2DM patients with
central obesity took part. The overall prevalence of
hyperuricemia was 32.6% (36.1% for women, 28.4% for men). Binary logistic regression analyses demonstrated that women (OR: 1.576; 95% confidence interval (CI): 1.231, 2.018), high BMI (OR: 1.228; 95% CI: 1.094, 1.379), waist cir-cumference (OR: 1.135; 95% CI: 1.009, 1.276),
hypertension (OR: 1.603; 95% CI: 1.263, 2.035), high total cho-lesterol (OR: 1.133; 95% CI: 1.002, 1.281),
triglycerides (OR: 1.134; 95% CI: 1.069, 1.203), low
HDL-cholesterol (OR: 0.820; 95% CI: 0.677, 0.995) and low estimated glomerular filtration rate (OR: 0.840; 95% CI: 0.815, 0.866) were risk factors associated with
hyperuricemia.
Hyperuricemia is prevalent in Chinese T2DM patients with
central obesity and is significantly positively associated with women, cardiovascular risk factors such as
obesity,
hypertension and
dyslipidemia, and low eGFR.