Abstract | PURPOSE: METHODS: Total of 174 pediatric patients (age range, 1 to 19 years) with inflammatory bowel disease who received azathioprine in order to maintain remission at Samsung Medical Center (Seoul, Korea) from January 2002 through December 2012 were included in this study. Medical records of these subjects were retrospectively reviewed regarding the development of adverse events associated with azathioprine treatment. RESULTS: Ninety-eight patients (56.3%) of 174 patients experienced 136 episodes of adverse events, requiring dose reduction in 31 patients (17.8%), and discontinuation in 18 patients (10.3%). The mean dose of azathioprine that had been initially administered was 1.32±0.42 mg/kg/day. Among the adverse reactions, bone marrow suppression developed in 47 patients (27.0%), requiring dose reduction in 22 patients (12.6%) and discontinuation in 8 patients (4.6%). Other adverse events that occurred were gastrointestinal disturbance (15.5%), hair loss (12.1%), pancreatitis (7.5%), arthralgia (6.9%), hepatotoxicity (2.9%), skin rash/ allergic reactions (2.9%), headache/ dizziness (2.3%), sepsis (0.6%), and oral mucositis (0.6%). CONCLUSION:
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Authors | Ji Young Chun, Ben Kang, Yoo Min Lee, Soo Youn Lee, Mi Jin Kim, Yon Ho Choe |
Journal | Pediatric gastroenterology, hepatology & nutrition
(Pediatr Gastroenterol Hepatol Nutr)
Vol. 16
Issue 3
Pg. 171-7
(Sep 2013)
ISSN: 2234-8646 [Print] Korea (South) |
PMID | 24224150
(Publication Type: Journal Article)
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