Abstract |
During our ongoing screening program designed to determine the anti-inflammatory potential of natural compounds, we isolated sargachromenol from Sargassum micracanthum. In the present study, we investigated the anti-inflammatory effects of sargachromenol on lipopolysaccharide (LPS)-induced inflammation in murine RAW 264.7 macrophage cells and the underlying mechanisms. Sargachromenol significantly inhibited the LPS-induced production of nitric oxide (NO) and prostaglandin E₂ (PGE₂) in a dose-dependent manner. It also significantly inhibited the protein expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner in LPS-stimulated macrophage cells. Further analyses showed that sargachromenol decreased the cytoplasmic loss of inhibitor κBα (IκBα) protein. These results suggest that sargachromenol may exert its anti-inflammatory effects on LPS-stimulated macrophage cells by inhibiting the activation of the NF-κB signaling pathway. In conclusion, to our knowledge, this is the first study to show that sargachromenol isolated from S. micracanthum has an effective anti-inflammatory activity. Therefore, sargachromenol might be useful for cosmetic, food, or medical applications requiring anti-inflammatory properties.
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Authors | Eun-Jin Yang, Young Min Ham, Kyong-Wol Yang, Nam Ho Lee, Chang-Gu Hyun |
Journal | TheScientificWorldJournal
(ScientificWorldJournal)
Vol. 2013
Pg. 712303
( 2013)
ISSN: 1537-744X [Electronic] United States |
PMID | 24194688
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Benzopyrans
- Inflammation Mediators
- Lipopolysaccharides
- sargachromenol
- Nitric Oxide
- Dinoprostone
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Topics |
- Animals
- Anti-Inflammatory Agents
(administration & dosage)
- Benzopyrans
(administration & dosage, metabolism)
- Cell Line
- Dinoprostone
(immunology)
- Inflammation
(chemically induced, immunology, prevention & control)
- Inflammation Mediators
(immunology)
- Lipopolysaccharides
- Macrophage Activation
(drug effects, immunology)
- Macrophages
(drug effects, immunology)
- Mice
- Nitric Oxide
(immunology)
- Sargassum
(metabolism)
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