Serial Ga-67 citrate imaging in children with neoplastic disease: concise communication.

Abstract

To investigate the role of Ga-67 imaging in children with neoplastic disease, 83 Ga-67 scans, obtained in 46 children with neoplastic disease, were retrospectively analyzed. The series included 19 children who had two to five serial Ga-67 scans while undergoing therapy over periods as long as 4 yr. Three patterns were identified in the children who had serial Ga-67 imaging: a) twelve children with tumors that were initially gallium-avid had normal scans after chemotherapy and/or radiotherapy; b) four children had persistently positive Ga-67 scans while being treated; and c) three children with gallium-avid tumors developed a normal scan after therapy, but later had a gallium-avid recurrence. All 12 children in the first group were alive and clinically disease-free after a mean followup time of 38 mo. Six of the seven children with persistently gallium-avid tumors or gallium-avid recurrent tumors died during a mean followup time of 15.5 mo. The results of this small series suggest that further investigation is warranted to determine whether the results of serial Ga-67 imaging have any prognostic significance in children with neoplastic disease.

• Authors: S L Yang, P O Alderson, H A Kaizer, H N Wagner Jr
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 20 Issue 3 Pg. 210-4 (Mar 1979) ISSN: 0161-5505 [Print] United States
• PMID: 24180039 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Citrates
• Gallium
• gallium citrate

Topics

• Adolescent
• Child
• Child, Preschool
• Citrates
• Disease-Free Survival
• Female
• Gallium
• Humans
• Image Interpretation, Computer-Assisted
• Infant
• Male
• Neoplasms (diagnostic imaging)
• Radionuclide Imaging
• Retrospective Studies
• Time Factors