Protamine sulfate-nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells.

Abstract

We report an innovative approach for miRNA-203 delivery in esophageal cancer cells using protamine sulphate (PS)-nanodiamond (ND) nanoparticles. The efficient delivery of miR-203 significantly suppressed the proliferation and migration of cancer cells through targeting Ran and ΔNp63, exhibiting a great potential for PS@ND nanoparticles in miRNA-based cancer therapy.

• Authors: Minjun Cao, Xiongwei Deng, Shishuai Su, Fang Zhang, Xiangqian Xiao, Qin Hu, Yongwei Fu, Burton B Yang, Yan Wu, Wang Sheng, Yi Zeng
• Journal: Nanoscale (Nanoscale) Vol. 5 Issue 24 Pg. 12120-5 (Dec 21 2013) ISSN: 2040-3372 [Electronic] England
• PMID: 24154605 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Carriers
• MIRN203 microRNA, human
• MicroRNAs
• Nanodiamonds
• Protamines
• RNA, Small Interfering

Topics

• Carcinoma, Squamous Cell (genetics, pathology, therapy)
• Cell Line, Tumor
• Drug Carriers (chemistry)
• Esophageal Neoplasms (genetics, pathology, therapy)
• Gene Expression Regulation, Neoplastic
• Gene Transfer Techniques
• Genetic Therapy (methods)
• Humans
• MicroRNAs (genetics)
• Nanodiamonds (chemistry, therapeutic use)
• Nanoparticles (chemistry, therapeutic use)
• Protamines (chemistry, therapeutic use)
• RNA, Small Interfering (administration & dosage)