Level of TNF-related apoptosis-inducing-ligand and CXCL8 correlated with 2-[18F]Fluoro-2-deoxy-D-glucose uptake in anti-VEGF treated colon cancers.

Abstract

BACKGROUND:

The changes and correlations of TRAIL (TNF-related apoptosis-inducing-ligand) and CXCL8 (IL8) prior to treatment and three months following therapy as well as the corresponding Positron emission tomography (PET/CT) (SUV(max): standardized uptake maximum values) results were evaluated.

MATERIAL AND METHODS:

The measurements were taken before and after treatment for comparison purposes. The study population comprised 29 patients with Metastatic Colorectal cancer (MCRC), undergoing PET/CT scanning prior to treatment.

RESULTS:

There were significant changes prior to treatment and three months later for sTRAIL (p=0.0080) and CXCL8 (p=0.0001)values. Generally, sTRAIL values were increasing during therapy, while a decrease was observed for CXCL8. Correlation analysis was applied to the data and revealed significant correlations for the SUV(max) in the primary tumor prior to treatment and CXCL8 prior to therapy (p=0.0303). Furthermore, significant correlations were observed for the SUV(max) and sTRAIL (p=0.0237) as well as CXCL8 (p=0.0002) three months after treatment initiation. CXCL8 prior to treatment was also correlated with the SUV three months after onset of treatment (p=0.0072). A significant correlation was noted for one combination of two variables, the SUV(max) in the metastases and CXCL8 prior to treatment (p=0.0175). These results are supported when we group the SUV(max) in the metastases following treatment into two groups with SUV(max) <5 and SUV(max) >5.

CONCLUSIONS:

This study provides evidence that proteomics patterns of sTRAIL and CXCL8 predict tumor response und survival in MCRC patients treated with bevacizumab and within a high concordance of FDG-PET/CT findings.

• Authors: Betül Celik, Arzu Didem Yalcin, Atil Bisgin, Antonia Dimitrakopoulou-Strauss, Aysegül Kargi, Ludwig G Strauss
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 19 Pg. 875-82 (Oct 21 2013) ISSN: 1643-3750 [Electronic] United States
• PMID: 24145180 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal, Humanized
• CXCL8 protein, human
• Fluorine Radioisotopes
• Interleukin-8
• TNF-Related Apoptosis-Inducing Ligand
• TNFSF10 protein, human
• Fluorodeoxyglucose F18
• Bevacizumab

Topics

• Antibodies, Monoclonal, Humanized (therapeutic use)
• Bevacizumab
• Colonic Neoplasms (blood, drug therapy)
• Fluorine Radioisotopes (pharmacokinetics)
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Humans
• Interleukin-8 (blood)
• Positron-Emission Tomography
• Proteomics
• Statistics, Nonparametric
• TNF-Related Apoptosis-Inducing Ligand (blood)