Abstract | IMPORTANCE: OBSERVATIONS: A 46-year-old white woman with a history of Fms-like tyrosine kinase 3 acute myeloid leukemia presented to the dermatology clinic with a 5-day history of a nonpruritic eruption on her face and neck 28 days after undergoing a double umbilical cord blood hematopoietic stem cell transplant (HSCT). Findings from the skin biopsy demonstrated a deep dermal lymphocytic infiltrate adjacent to follicular units along with an abundance of Demodex mites noted within the hair follicles consistent with Demodex folliculitis. Oral ivermectin, 12 mg, was given, and the eruption cleared within 24 hours. CONCLUSIONS AND RELEVANCE: To our knowledge, this is only the fifth reported case of Demodex folliculitis following HSCT, but the first ever reported to be successfully treated with oral ivermectin. Demodex folliculitis should be added to the differential diagnosis of skin eruptions that arise after HSCT.
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Authors | Jonathan Cotliar, Olga Frankfurt |
Journal | JAMA dermatology
(JAMA Dermatol)
Vol. 149
Issue 12
Pg. 1407-9
(Dec 2013)
ISSN: 2168-6084 [Electronic] United States |
PMID | 24132559
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antiparasitic Agents
- Ivermectin
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Topics |
- Animals
- Antiparasitic Agents
(therapeutic use)
- Biopsy
- Diagnosis, Differential
- Face
- Female
- Folliculitis
(diagnosis, drug therapy, parasitology)
- Graft vs Host Disease
(diagnosis, pathology)
- Hematopoietic Stem Cell Transplantation
- Humans
- Ivermectin
(therapeutic use)
- Middle Aged
- Mite Infestations
(diagnosis, drug therapy, pathology)
- Mites
- Neck
- Skin
(parasitology, pathology)
- Treatment Outcome
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