HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Neurologic improvement without angiographic improvement after antithyroid therapy in a patient with Moyamoya syndrome.

Abstract
Moyamoya disease with special complications, including Graves' disease, is called as moyamoya syndrome. A 22-year-old Japanese woman had left middle cerebral artery (MCA) territory infarction complicated with Graves' disease. She had right-sided hemiparesis that deteriorated on day 8 with the infarct growth and thyrotoxicosis. On angiogram, the left MCA was occluded at the origin without moyamoya vessels. Positron emission tomography (PET) revealed misery-perfusion phenomenon in the left MCA territory. After initiation of the antithyroid therapy, her hemiparesis became milder. Seventeen months later, her thyroid function was normalized and net-like collateral moyamoya vessels proliferated in the left MCA territory. Misery-perfusion phenomenon persisted on PET. This report is unique in the point of neurologic recovery of the moyamoya patient right after initiation of antithyroid medication without radiological improvement.
AuthorsAkiko Ishigami, Kazunori Toyoda, Rieko Suzuki, Fumio Miyashita, Koji Iihara, Kazuo Minematsu
JournalJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) 2014 May-Jun Vol. 23 Issue 5 Pg. 1256-8 ISSN: 1532-8511 [Electronic] United States
PMID24119625 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Antithyroid Agents
Topics
  • Antithyroid Agents (therapeutic use)
  • Cerebral Angiography
  • Cerebrovascular Circulation
  • Collateral Circulation
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Graves Disease (diagnosis, drug therapy, etiology, physiopathology)
  • Humans
  • Infarction, Middle Cerebral Artery (diagnosis, drug therapy, etiology, physiopathology)
  • Moyamoya Disease (complications, diagnosis, drug therapy, physiopathology)
  • Neovascularization, Physiologic
  • Perfusion Imaging (methods)
  • Positron-Emission Tomography
  • Recovery of Function
  • Treatment Outcome
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: