Abstract | BACKGROUND AND OBJECTIVE: METHODS: RESULTS: During a median follow-up of 3.1 years (interquartile range, 2.5-3.5), a total of 316 (31.5%) MACEs were recorded. Increased levels of MPV were significantly associated with increased risk of the occurrence of MACEs (adjusted hazard ratio [HR] for an increase in one standard deviation [SD] of MPV 1.22, confidence interval [CI] 1.05-1.35, P < 0.01). Patients with MPV levels above 11.8 femtolitre (= fifth quintile) had a significantly higher event rate (41.3% vs. 29.3%, P < 0.001) with an adjusted HR for MACEs of 1.65 (95% CI 1.26-2.16, P < 0.001) compared with patients with MPV levels in the first to fourth quintile. No significant association was found between baseline MPV levels with either baseline degree or progression during a 6-month follow-up of carotid stenosis. CONCLUSION: Mean platelet volume was independently and significantly associated with adverse cardiovascular outcome in patients with asymptomatic carotid atherosclerosis.
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Authors | Florian J Mayer, Matthias Hoke, Martin Schillinger, Erich Minar, Itziar Arbesú, Renate Koppensteiner, Christine Mannhalter |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 44
Issue 1
Pg. 22-8
(Jan 2014)
ISSN: 1365-2362 [Electronic] England |
PMID | 24117332
(Publication Type: Journal Article)
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Copyright | © 2013 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd. |
Topics |
- Aged
- Asymptomatic Diseases
- Atherosclerosis
(blood, complications, mortality)
- Carotid Artery Diseases
(blood, complications, mortality)
- Carotid Artery, Internal
(diagnostic imaging)
- Carotid Stenosis
(blood, complications, mortality)
- Cohort Studies
- Coronary Artery Bypass
(statistics & numerical data)
- Disease Progression
- Female
- Humans
- Male
- Mean Platelet Volume
- Middle Aged
- Myocardial Infarction
(complications, mortality)
- Percutaneous Coronary Intervention
(statistics & numerical data)
- Prognosis
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Stroke
(complications, mortality)
- Ultrasonography
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