Abstract | BACKGROUND AND PURPOSE: METHODS: A French SNMG database was created and the sera from the 37 patients included in it were analysed by immunofluorescence of cell-based assays using cotransfection of AChR subunit genes together with rapsyn to densely cluster the AChRs. RESULTS: CONCLUSIONS: Patients with antibodies to clustered AChR account for a significant proportion of SNMG patients and resemble patients with AChR antibodies detected by standard radio-immunoprecipitation.
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Authors | P Devic, P Petiot, T Simonet, T Stojkovic, E Delmont, J Franques, A Magot, C Vial, E Lagrange, A S Nicot, V Risson, B Eymard, L Schaeffer |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 21
Issue 1
Pg. 130-4
( 2014)
ISSN: 1468-1331 [Electronic] England |
PMID | 24112557
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 The Author(s) European Journal of Neurology © 2013 EFNS. |
Chemical References |
- Autoantibodies
- Autoantigens
- Receptors, Cholinergic
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Topics |
- Adolescent
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Autoantibodies
(blood)
- Autoantigens
(immunology)
- Databases, Factual
- Female
- Fluorescent Antibody Technique
- France
- Humans
- Male
- Middle Aged
- Myasthenia Gravis
(immunology)
- Phenotype
- Receptors, Cholinergic
(immunology)
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