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Multiple system atrophy.

Abstract
Multiple system atrophy (MSA) is a sporadic and fatal α-synuclein-linked oligodendrogliopathy manifesting with progressive autonomic failure, poorly levodopa-responsive parkinsonism, and cerebellar ataxia, in any combination. Here we review key aspects of MSA integrating important insights from rapidly emerging fields such as genetics, diagnostic work-up including imaging, and translational therapies aimed at disease modification.
AuthorsGregor K Wenning, Florian Krismer
JournalHandbook of clinical neurology (Handb Clin Neurol) Vol. 117 Pg. 229-41 ( 2013) ISSN: 0072-9752 [Print] Netherlands
PMID24095129 (Publication Type: Journal Article, Review)
Copyright© 2013 Elsevier B.V. All rights reserved.
Topics
  • Disease Progression
  • Humans
  • Magnetic Resonance Imaging
  • Multiple System Atrophy (diagnosis, epidemiology, therapy)

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