Effect of intestinal function-recovering decoction on treatment of multiple organ dysfunction syndrome in rats.

Abstract

OBJECTIVE:

To analyze the effect of intestinal function-recovering decoction on multiple organ dysfunction syndrome in rats, and to investigate a novel solution to multiple organ dysfunction syndrome.

METHODS:

Multiple organ dysfunction syndrome was induced in 60 Sprague-Dawley rats by intestinal ischemia-reperfusion combined with cecal ligation and puncture. Then these rats were intragastrically administered physiological saline (group I, n=20), ampicillin (group II, n=20) or intestinal function-recovering decoction (group III, n=20). After treatment, serum malondialdehyde and superoxide dismutase levels were compared among three groups. Simultaneously, bacterial culture of various organ tissues was performed and bacterial and endotoxin translocation were observed.

RESULTS:

Compared with group I, serum malondialdehyde, alanine aminotransferase and aspartate aminotransferase levels were significantly decreased (all P<0.05) and serum superoxide dismutase level was significantly increased (P<0.05) in the group III. However, there were no significant differences in these indices between groups II and III (P>0.05). The rate of bacterial translocation in the groups II and III was significantly lower than in the group I (P<0.05), and no significant difference was observed between groups II and III (P>0.05).

CONCLUSIONS:

Intestinal function-recovering decoction can significantly reduce endotoxin and bacterial translocation and stabilize enteral oxidative-antioxidative balance.

• Authors: Shu-Jie Zhao, Dong Zhang, Shi-Ji Wang, Ying Chen, Jin-Feng Han, Yu-Shan Wang
• Journal: Asian Pacific journal of tropical medicine (Asian Pac J Trop Med) Vol. 6 Issue 11 Pg. 889-92 (Nov 2013) ISSN: 2352-4146 [Electronic] India
• PMID: 24083585 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Drugs, Chinese Herbal
• Endotoxins
• Malondialdehyde
• Ampicillin
• Superoxide Dismutase

Topics

• Ampicillin (pharmacology)
• Animals
• Anti-Bacterial Agents (pharmacology)
• Bacterial Translocation
• Disease Models, Animal
• Drugs, Chinese Herbal (pharmacology)
• Endotoxins (blood)
• Female
• Intestinal Mucosa (drug effects, microbiology, physiopathology)
• Male
• Malondialdehyde (blood)
• Multiple Organ Failure (drug therapy, microbiology, physiopathology)
• Rats
• Rats, Sprague-Dawley
• Superoxide Dismutase (blood)