A new aminothiazolylcephalosporin having 1-carboxyethoxyimino group, ME1228.

Abstract	Aminothiazolylacetamidocephalosporins having 1-carboxyethoxyimino groups were synthesized and found to have excellent antibacterial activities including anti-pseudomonal activity and low toxicities. Among these cephalosporins, ME1228 having (S)-1-carboxyethoxyimino substituent and being combined with an (N-ethyl-4-pyridinio)thiomethyl group at C-3 showed marked therapeutic effects against systemic infections in mice and was selected as the best candidate for further evaluation.
Authors	S Shibahara, T Okonogi, T Yoshida, Y Murai, T Kudo, S Inouye, S Kondo
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 43 Issue 1 Pg. 62-9 (Jan 1990) ISSN: 0021-8820 [Print] England
PMID	2407708 (Publication Type: Journal Article)
Chemical References	Cephalosporins ME 1228
Topics	Animals Bacteria (drug effects) Bacterial Infections (drug therapy) Cephalosporins (chemical synthesis, pharmacology, therapeutic use, toxicity) Chemical Phenomena Chemistry Escherichia coli Infections (drug therapy) Isomerism Male Mice Mice, Inbred ICR Pseudomonas Infections (drug therapy)

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