Abstract | BACKGROUND: METHODS: RESULTS: Anti-D1R and anti-D2R autoantibodies were significantly higher in SC compared to controls (n = 44; p = 0.010 and p = 0.017, respectively). We found that the ratio (anti-D2R/D1R) of the two anti-dopaminergic receptor antibodies correlated with neuropsychiatric symptoms as determined by USCRS measurements (n = 18; r = 0.53, p = 0.024). In addition, anti-D2R titers correlated with antistreptolysin-O titers (n = 43; r = 0.49, p = 0.0008). INTERPRETATION: Our report linked, for the first time, autoimmunity with neuropsychiatric symptoms. The significant correlation was found using ratios of autoantibodies against dopamine receptors (anti-D2R/D1R) rather than the absolute elevated individual anti-D1R or anti-D2R titers. We suggest that autoantibodies may lead to a receptor imbalance and induce greater sensitivity to dopamine signaling potentially leading to neuropsychiatric symptoms in SC. Our novel findings suggesting altered balance in the dopaminergic system may provide a new approach in understanding autoimmune neuropsychiatric disorders with possible implications for diagnosis and treatment.
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Authors | Hilla Ben-Pazi, Julie A Stoner, Madeleine W Cunningham |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 9
Pg. e73516
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24073196
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Receptors, Dopamine D1
- Receptors, Dopamine D2
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Topics |
- Adolescent
- Adult
- Autoantibodies
(blood)
- Case-Control Studies
- Child
- Child, Preschool
- Chorea
(diagnosis, immunology, microbiology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Male
- Prognosis
- Receptors, Dopamine D1
(immunology)
- Receptors, Dopamine D2
(immunology)
- Streptococcal Infections
(diagnosis, immunology, microbiology)
- Young Adult
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