Severe leukemoid reaction in a preterm infant with congenital cytomegalovirus infection.

Abstract

Leukemoid reaction, defined as a total leukocyte count of >50,000/mm, is most commonly related to antenatal administration of steroids, infections, and transient myeloproliferative disorder of Down syndrome in newborns. Atypical presentations of viral infections can be a diagnostic challenge in the newborn period. Cytomegalovirus (CMV) infection causes a multisystem disease, and symptomatic infants generally present with intrauterine growth restriction, hepatosplenomegaly, cholestasis, rash, thrombocytopenia, and microcephaly. We present a case of a preterm infant with severe myeloid leukemoid reaction (leukocyte count >100,000/mm) at birth who was diagnosed with congenital CMV infection on the basis of CMV polymerase chain reaction results after the appearance of cholestasis, blueberry muffin rash, and hepatosplenomegaly.

• Authors: Dilek U Isik, Ozge Aydemir, Yusuf Kale, Husniye Yucel, Ahmet Y Bas, Nihal Demirel, Nilufer Arda, Sema Apaydin
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 36 Issue 5 Pg. e310-2 (Jul 2014) ISSN: 1536-3678 [Electronic] United States
• PMID: 24072252 (Publication Type: Case Reports, Journal Article)

Chemical References

• DNA, Viral

Topics

• Cytomegalovirus Infections (congenital, diagnosis)
• DNA, Viral (genetics)
• Humans
• Infant, Newborn
• Infant, Premature
• Leukemoid Reaction (diagnosis)
• Leukocyte Count
• Male
• Polymerase Chain Reaction
• Prognosis