Abstract | BACKGROUND: METHODS: During the pandemic, the German ARDS Network (a task force of the DIVI's respiratory failure section) kept track of the availability of ECMO treatment facilities with a day-to-day, Internet-based capacity assessment. In cooperation with the Robert Koch Institute, epidemiological and clinical data were obtained on all patients treated for influenza in intensive care units. RESULTS: 116 patients were identified who had H1N1 disease and were treated in the intensive care units of 9 university hospitals and 3 other maximum medical care hospitals. 61 of them received ECMO. The overall mortality was 38% (44 of 116 patients); among patients receiving ECMO, the mortality was 54% (33 of 61 patients). The mortality was higher among patients who had an accompanying malignancy or immune deficiency (72.2%). CONCLUSION: Even persons without any other accompanying disease developed life-threatening respiratory failure as a result of H1N1 infection, and many of these patients needed ECMO. This study reveals for the first time that the mortality of H1N1 infection in Germany is comparable to that in other countries. H1N1 patients with acute respiratory failure had a worse outcome if they also had serious accompanying diseases.
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Authors | Steffen Weber-Carstens, Anton Goldmann, Michael Quintel, Armin Kalenka, Stefan Kluge, Jürgen Peters, Christian Putensen, Thomas Müller, Simone Rosseau, Bernhard Zwißler, Onnen Moerer |
Journal | Deutsches Arzteblatt international
(Dtsch Arztebl Int)
Vol. 110
Issue 33-34
Pg. 543-9
(Aug 2013)
ISSN: 1866-0452 [Electronic] Germany |
PMID | 24069078
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Topics |
- Acute Disease
- Adult
- Age Distribution
- Causality
- Community Networks
(statistics & numerical data)
- Comorbidity
- Extracorporeal Membrane Oxygenation
(mortality)
- Female
- Germany
(epidemiology)
- Humans
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
(mortality, therapy, virology)
- Male
- Middle Aged
- Pandemics
(prevention & control, statistics & numerical data)
- Prevalence
- Respiratory Distress Syndrome
(mortality, therapy, virology)
- Retrospective Studies
- Risk Factors
- Sex Distribution
- Survival Rate
- Treatment Outcome
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