Abstract | BACKGROUND: Plasmodium vivax infection has been considered a benign and self-limiting disease, however, recent studies highlight the association between vivax malaria and life-threatening manifestations. Increase in reactive oxygen species has already been described in vivax malaria, as a result of the increased metabolic rate triggered by the multiplying parasite, and large quantities of toxic redox-active byproducts generated. The present study aimed to study the oxidative stress responses in patients infected with P. vivax, who developed jaundice (hyperbilirubinaemia) in the course of the disease, a common clinical complication related to this species. METHODS: RESULTS: CONCLUSION: Cholestatic hyperbilirubinaemia in vivax malaria cannot be totally disassociated from malaria-related haemolysis. However, significant increase of lipid peroxidation markers and changes in antioxidant enzymes in patients with P. vivax-related jaundice was observed. These results suggest oxidative processes contributing to malaria pathogenesis, what may be useful information for future anti-oxidant therapeutical interventions in these patients.
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Authors | Camila Fabbri, Rita de Cássia Mascarenhas-Netto, Pritesh Lalwani, Gisely C Melo, Belisa M L Magalhães, Márcia A A Alexandre, Marcus V G Lacerda, Emerson S Lima |
Journal | Malaria journal
(Malar J)
Vol. 12
Pg. 315
(Sep 10 2013)
ISSN: 1475-2875 [Electronic] England |
PMID | 24020374
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Antioxidants
(metabolism)
- Female
- Humans
- Jaundice, Obstructive
(pathology)
- Lipid Peroxidation
- Malaria, Vivax
(complications, pathology)
- Male
- Middle Aged
- Young Adult
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