[4-allyloxy-3-chlorophenyl-acetic acid (alclofenac) in the treatment of painful arthroses in the aged. Double-blind controlled clinical trial].

Abstract

The antiarthrosic effectiveness with respect to spontaneous pain upon movement and pressure, of alclofenac (4-allyloxy-3-chlorophenyl-acetic acid) was tested in a homogeneous group of elderly patients and compared with orally administered indomethacin. The research was carried out in strictly controlled, double-blind experimental conditions. The results obtained suggest that 500 mg of the new anti-inflammatory analgesic have the same action as 25 mg of indomethacin but with a lower incidence of the side effects common to all anti-inflammatory substances. Thanks to its good tolerability and high effectiveness, the new drug should be of considerable utility in the treatment of arthrosis in the elderly and in painful, inflammatory complications.

• Authors: G Ziliotto, G Lamberti
• Journal: Minerva medica (Minerva Med) Vol. 66 Issue 57 Pg. 2823-34 (Sep 05 1975) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: L'acido 4-allilossi-3-clorofenilacetico (alclofenac) nel trattamento dell'artrosi dolorosa dell'anziano. Sperimentazione clinica controllata a doppia cecità
• PMID: 240140 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Phenylacetates
• Indomethacin

Topics

• Aged
• Clinical Trials as Topic
• Drug Evaluation
• Female
• Humans
• Indomethacin (therapeutic use)
• Joint Diseases (drug therapy)
• Middle Aged
• Pain (drug therapy)
• Phenylacetates (therapeutic use)