Efficacy of two FDA-approved drug combination in a mouse model of staphylococcal enterotoxin B-induced shock.

Abstract

Staphylococcal enterotoxin B (SEB) causes lethal shock by potently stimulating the host immune response. Dexamethasone and N-acetyl cysteine (NAC) are anti-inflammatory and antioxidative drugs, respectively, which can independently modulate immune function. Dexamethasone was previously shown to be effective in preventing SEB-induced shock models only if administered early and in multiple doses for a long duration. In this study, dexamethasone and NAC were used in tandem and protected mice (75%) against SEB-induced lethal shock. Hypothermia and weight loss elicited by SEB were also diminished by this novel combination treatment. The levels of monocyte chemoattractant protein-1, interleukin-2, interleukin-6, and mouse gamma interferon in lung tissue after intranasal exposure to SEB were also significantly reduced in mice given a combination of dexamethasone and NAC versus controls.

• Authors: Teresa Krakauer, Marilyn Buckley
• Journal: Military medicine (Mil Med) Vol. 178 Issue 9 Pg. 1024-8 (Sep 2013) ISSN: 1930-613X [Electronic] England
• PMID: 24005553 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Reprint & Copyright © 2013 Association of Military Surgeons of the U.S.

Chemical References

• Anti-Inflammatory Agents
• Chemokine CCL2
• Enterotoxins
• Free Radical Scavengers
• Interleukin-2
• Interleukin-6
• enterotoxin B, staphylococcal
• Dexamethasone
• Interferon-gamma
• Acetylcysteine

Topics

• Acetylcysteine (therapeutic use)
• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Chemokine CCL2 (metabolism)
• Dexamethasone (therapeutic use)
• Disease Models, Animal
• Drug Therapy, Combination
• Enterotoxins
• Female
• Free Radical Scavengers (therapeutic use)
• Interferon-gamma (metabolism)
• Interleukin-2 (metabolism)
• Interleukin-6 (metabolism)
• Lung (metabolism)
• Male
• Mice
• Shock, Septic (blood, chemically induced, drug therapy)