[Immunomodulating mechanism of the antitumor effect of asterin].

Abstract

It was shown that asterin therapy performed on a model of spontaneous metastasis markedly changed the content of the thymus serum factor in mice and normalized its level. The inducing mechanism of the drug's antitumor action was realized both at the stage of the metastatic postinvasion phase and during its terminal period which was probably due to an increase in the influence of the thymus on the immune system and evident from an increase in the therapeutic action of the drug.

• Authors: V V Smirnov, E L Mishenkova, Iu A Grinevich, G T Petrenko, S V Martynenko
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 35 Issue 6 Pg. 31-4 (Jun 1990) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Immunomoduliruiushchiĭ mekhanizm protivoopukholevogo deĭstviia asterina.
• PMID: 2400290 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Lewis Blood Group Antigens
• Plant Extracts

Topics

• Adjuvants, Immunologic
• Animals
• Female
• Immune Tolerance (drug effects, immunology)
• Lewis Blood Group Antigens (immunology)
• Lung Neoplasms (drug therapy, immunology)
• Male
• Mice
• Mice, Inbred C57BL
• Neoplasms, Experimental (immunology)
• Plant Extracts (therapeutic use)
• T-Lymphocytes (drug effects, immunology)