Chronic intermittent hypoxia preserves bone density in a mouse model of sleep apnea.

Abstract

Very recent clinical research has investigated whether obstructive sleep apnea (OSA) may modulate bone homeostasis but the few data available are conflicting. Here we report novel data obtained in a mouse study specifically designed to determine whether chronic intermittent hypoxia realistically mimicking OSA modifies bone mineral density (BMD). Normal male and female mice and orchidectomized mice (N=10 each group) were subjected to a pattern of high-frequency intermittent hypoxia (20s at 5% and 40s at 21%, 60 cycles/h) for 6h/day. Identical groups breathing room air (normoxia) were the controls. After 32 days of intermittent hypoxia/normoxia the trabecular bone mineral density (BMD) in the peripheral femora were measured by micro-CT scanning. When compared with normoxia (two-way ANOVA), intermittent hypoxia did not significantly modify BMD in the three animal groups tested. Data in this study suggest that the type of intermittent hypoxia characterizing OSA, applied as a single challenge, preserves bone homeostasis.

• Authors: Marta Torres, Josep M Montserrat, Javier Pavía, Mireia Dalmases, Domenec Ros, Yolanda Fernandez, Ferran Barbé, Daniel Navajas, Ramon Farré
• Journal: Respiratory physiology & neurobiology (Respir Physiol Neurobiol) Vol. 189 Issue 3 Pg. 646-8 (Dec 01 2013) ISSN: 1878-1519 [Electronic] Netherlands
• PMID: 23994179 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Topics

• Absorptiometry, Photon
• Analysis of Variance
• Animals
• Bone Density
• Bone Diseases (etiology, prevention & control)
• Disease Models, Animal
• Female
• Hypoxia (physiopathology)
• Male
• Mice
• Mice, Inbred C57BL
• Sex Characteristics
• Sleep Apnea Syndromes (complications)
• Statistics, Nonparametric