Abstract | INTRODUCTION: AREAS COVERED: This review describes the pharmacology, pharmacokinetics, efficacy, safety, and potential role in therapy of mitiglinide therapy. Phase II and III clinical studies have demonstrated that A1C levels should be expected to decrease by 0.17 - 1.1% with mitiglinide therapy. The most common adverse effects in these studies were hypoglycemia related. EXPERT OPINION: Meglitinides are limited by their cost, frequency of administration, and minimal available data assessing clinical impact; however, mitiglinide shows selective action on the pancreatic β-cells, has greater affinity for β-cells, and limited metabolism when compared to other meglitinides. These properties may allow more utility in patients with chronic kidney disease or at high risk of hypoglycemia. The primary role in therapy for mitiglinide is the treatment of elevated postprandial glucose in patients with T2DM.
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Authors | Haley M Phillippe, Kurt A Wargo |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 14
Issue 15
Pg. 2133-44
(Oct 2013)
ISSN: 1744-7666 [Electronic] England |
PMID | 23992284
(Publication Type: Journal Article, Review)
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Chemical References |
- Hypoglycemic Agents
- Isoindoles
- mitiglinide
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Topics |
- Diabetes Mellitus, Type 2
(drug therapy)
- Humans
- Hypoglycemic Agents
(pharmacology, therapeutic use)
- Isoindoles
(pharmacology, therapeutic use)
- Treatment Outcome
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