The role of nesfatin-1 in the regulation of food intake and body weight: recent developments and future endeavors.

Abstract

Nesfatin-1 was discovered in 2006 and introduced as a potential novel anorexigenic modulator of food intake and body weight. The past years have witnessed increasing evidence establishing nesfatin-1 as a potent physiological inhibitor of food intake and body weight and unravelled nesfatin-1's interaction with other brain transmitters to exert its food consumption inhibitory effect. As observed for other anorexigenic brain neuropeptides, nesfatin-1 is also likely to exert additional, if not pleiotropic, actions in the brain and periphery. Recent studies established the prominent expression of the nesfatin-1 precursor, nucleobindin2 (NUCB2), in the stomach and pancreas, where nesfatin-1 influences endocrine secretion. This review will highlight the current experimental state-of-knowledge on the effects of NUCB2/nesfatin-1 on food intake, body weight and glucose homeostasis. Potential implications in human obesity will be discussed in relation to the evidence of changes in circulating levels of NUCB2/nesfatin-1 in disease states, the occurrence of genetic NUCB2 polymorphisms and--in contrast to several other hormones--the independence of leptin signalling known to be blunted under conditions of chronically increased body weight.

• Authors: A Stengel, M Mori, Y Taché
• Journal: Obesity reviews : an official journal of the International Association for the Study of Obesity (Obes Rev) Vol. 14 Issue 11 Pg. 859-70 (Nov 2013) ISSN: 1467-789X [Electronic] England
• PMID: 23980879 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2013 The Authors. obesity reviews © 2013 International Association for the Study of Obesity.

Chemical References

• Calcium-Binding Proteins
• DNA-Binding Proteins
• Leptin
• NUCB2 protein, human
• Nerve Tissue Proteins
• Nucleobindins

Topics

• Animals
• Appetite Regulation (genetics)
• Body Weight (genetics)
• Calcium-Binding Proteins (genetics, physiology)
• DNA-Binding Proteins (genetics, physiology)
• Forecasting (methods)
• Humans
• Leptin (genetics, physiology)
• Nerve Tissue Proteins (genetics, physiology)
• Nucleobindins
• Obesity (etiology, genetics, metabolism)
• Signal Transduction (genetics)