Inhaled cisplatin deposition and distribution in lymph nodes in stage II lung cancer patients.

Abstract

Lung cancer therapies during the last decade have focused on targeting the genome of cancer cells, and novel routes for administering lung cancer therapies have been investigated for decades. Aerosol therapies for several systematic diseases and systemic infections were introduced into the market a decade ago. One of the main issues of aerosol therapies has been the ability to investigate the deposition of a drug compound throughout the systematic circulation and lymph node circulation. Until now, none of the published studies have efficiently shown the deposition of a chemotherapy pharmaceutical within the lymph node tissue. In our current work we present, for the first time, with the novel CytoViva(®) (AL, USA) technique, the deposition of cisplatin aerosol therapy in surgically resected stage II lymph nodes from lung cancer patients. Finally, we present the distribution of cisplatin in correlation with the cisplatin concentration in different lymph stations and comment on the possible mechanisms of distribution.

• Authors: Paul Zarogoulidis, Kaid Darwiche, Leslie Krauss, Haidong Huang, George A Zachariadis, Anna Katsavou, Wolfgang Hohenforst-Schmidt, Antonis Papaiwannou, Thomas J Vogl, Lutz Freitag, George Stamatis, Konstantinos Zarogoulidis
• Journal: Future oncology (London, England) (Future Oncol) Vol. 9 Issue 9 Pg. 1307-13 (Sep 2013) ISSN: 1744-8301 [Electronic] England
• PMID: 23980678 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Cisplatin

Topics

• Administration, Inhalation
• Antineoplastic Agents (pharmacokinetics, therapeutic use)
• Cisplatin (pharmacokinetics, therapeutic use)
• Humans
• Lung Neoplasms (drug therapy, pathology)
• Lymph Nodes (drug effects, pathology)
• Neoplasm Staging
• Tissue Distribution