[Nonspecific immunotherapy with BCG vaccine in bladder tumors].

Abstract

Clinical experience is recorded and summarized with the application of BCG vaccine for prophylaxis, treatment and immunochemotherapy of bladder tumors for the period June 1985-January 1988. Included in the study were 85 patients distributed in five groups: 23 patients treated for prevention of relapses; 26 treated for existing and residual surface tumors; 13 in whom BCG vaccine F-70 was applied for prophylaxis purpose; 17 with surface tumors treated only surgically--control group; 10 patients with advanced bladder tumor treated with immunochemotherapeutic agents. Once the results have been reported and discussed, the following inferences were made: 1. Intravesical BCG vaccine is a new effective and practicable method for prophylaxis and treatment of surface bladder tumors; 2. A 12-month course of treatment with the new Bulgarian Kalgevax showed high therapeutic activity; 3. Indications and possibilities for treatment of existing and residual surface tumors with intravesical BCG vaccine are given; complete effect of treatment was obtained in 21 patients (81 per cent); 4. The side reactions of the application of BCG vaccine and the possibilities for their reduction are presented; 5. The first results of application of immunotherapy in advanced bladder tumors are encouraging.

• Authors: Kh Damianov, T Patrashkov, Ts Petkov, T Tonchev, P Petrov
• Journal: Khirurgiia (Khirurgiia (Sofiia)) Vol. 43 Issue 1 Pg. 48-53 ( 1990) ISSN: 0450-2167 [Print] Bulgaria
• Vernacular Title: Nespetsifichna imunoterapiia s BTsZh vaksina pri tumori na pikochniia mekhur.
• PMID: 2395285 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• BCG Vaccine
• Epirubicin
• Cyclophosphamide
• Cisplatin

Topics

• Administration, Intravesical
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• BCG Vaccine (adverse effects, therapeutic use)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Drug Evaluation
• Epirubicin (administration & dosage)
• Humans
• Immunotherapy (adverse effects, methods)
• Injections, Intradermal
• Neoplasm Recurrence, Local (prevention & control)
• Postoperative Care
• Urinary Bladder Neoplasms (prevention & control, therapy)