Abstract | BACKGROUND: METHODS: Transient brain ischemia was induced for 60 min by intraluminal occlusion of the middle cerebral artery in 40 male Wistar rats under general anesthesia with s-ketamine and xylazine and with continuous monitoring of their blood pressure and cerebral perfusion. Five minutes before inducing reperfusion, a levosimendan bolus (24 μg kg -1) was administered over a 20 minute period. Infarct size, brain swelling, neurological function and the expression of inflammatory markers were quantified 24 hours after reperfusion. RESULTS: CONCLUSIONS:
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Authors | Marc Hein, Norbert Zoremba, Chistian Bleilevens, Christian Bruells, Rolf Rossaint, Anna B Roehl |
Journal | BMC neurology
(BMC Neurol)
Vol. 13
Pg. 106
(Aug 12 2013)
ISSN: 1471-2377 [Electronic] England |
PMID | 23937651
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydrazones
- Pyridazines
- Tumor Necrosis Factor-alpha
- Simendan
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Brain Ischemia
(prevention & control)
- Cerebrovascular Circulation
- Hydrazones
(pharmacology)
- Infarction, Middle Cerebral Artery
- Male
- Pyridazines
(pharmacology)
- Rats
- Rats, Wistar
- Reperfusion Injury
(drug therapy)
- Simendan
- Stroke
(pathology, prevention & control)
- Tumor Necrosis Factor-alpha
(genetics)
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