Abstract |
LupusPRO is a disease-targeted patient-reported outcome measure that was developed and validated from and among US patients with systemic lupus erythematosus (SLE). We herein report the results of the cross-cultural adaptation and validation study of the Turkish translated version of the LupusPRO. Turkish LupusPRO and the Medical Outcomes Study Short Form (SF-36) (Turkish) were administered to the Turkish lupus patients. Disease activity was ascertained using the physician global assessment ( PGA), Safety of Estrogens in Lupus Erythematosus National Assessment- Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI), and flare (defined by LFA-Lupus Foundation of America). Disease damage was assessed with Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SDI). Also, second Turkish LupusPRO tests were given to the patients to be completed within 2-3 days and sent back to us. Internal consistency reliability, test-retest reliability, and convergent and criterion validity (against disease activity or health status) were tested. All reported p values are two-tailed. The conceptual framework of the LupusPRO was evaluated using confirmatory factor analysis appropriate for categorical data. One hundred two SLE subjects (94 % women) were enrolled. The median (IQR) age and mean disease duration (±SD) were 38.5 (18) years and 60.3 (±56.3) months, respectively. The mean ± SD, SLEDAI, and SDI scores were 3.1 ± 3.7 and 0.52 ± 0.75, respectively. There were 25 patients who had flares at the time of study. Forty-two patients with no change in their health status completed and sent back the second LupusPRO test and were included in the test-retest analysis. Test-retest reliability of LupusPRO domains ranged from 0.87 to 0.97, while internal consistency reliability of the domains ranged from 0.63 to 0.94. Convergent validity with corresponding domains of SF-36 was present. Health-related quality-of-life domains performed well against disease activity measures ( PGA, total SLEDAI, LFA flare, and SF-6D-overall health status), establishing its criterion validity. Item-to-factor loadings representing the hypothesized item-to-scale relationships were satisfactory. The model fit for the hypothesized item-to-scale relationships was also satisfactory. The Turkish version of the LupusPRO is valid and appears to perform comparably to the English and Spanish language versions. It can be used as a patient-reported outcome parameter in clinical trials, as well as longitudinal studies for testing responsiveness to change.
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Authors | Arif Kaya, Berna Goker, Elife Senem Cura, Mehmet Engin Tezcan, Abdurrahman Tufan, Rıdvan Mercan, Berivan Bitik, Seminur Haznedaroglu, Mehmet Akif Ozturk, Rachel A Mikolaitis-Preuss, Joel A Block, Meenakshi Jolly |
Journal | Clinical rheumatology
(Clin Rheumatol)
Vol. 33
Issue 8
Pg. 1079-84
(Aug 2014)
ISSN: 1434-9949 [Electronic] Germany |
PMID | 23934384
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
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Topics |
- Adult
- Cross-Cultural Comparison
- Culture
- Factor Analysis, Statistical
- Female
- Health Status
- Humans
- Lupus Erythematosus, Systemic
(diagnosis)
- Male
- Middle Aged
- Quality of Life
- Reproducibility of Results
- Self Report
- Severity of Illness Index
- Surveys and Questionnaires
- Translations
- Turkey
- Young Adult
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