Utility of N-terminal pro-brain natriuretic peptide for assessing hemodynamic significance of patent ductus arteriosus in dogs undergoing ductal repair.

Abstract

OBJECTIVE:

Determine if plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) correlates with markers of hemodynamically significant patent ductus arteriosus (PDA) in dogs.

ANIMALS:

Ten dogs with PDA and 30 healthy dogs of similar ages.

METHODS:

Prospective case series with control population. Dogs with PDA were initially evaluated with thoracic radiographs, transthoracic echocardiography, pulmonary capillary wedge pressure (PCWP) and NT-proBNP. Following ductal occlusion, NT-proBNP and echocardiography were repeated within 24 h and at day 90. PCWP was repeated at day 90. Correlation between NT-proBNP and hemodynamic measurements was assessed, and accuracy of NT-proBNP for identifying PDA severity was estimated.

RESULTS:

NT-proBNP was significantly higher (median; absolute range) in dogs with PDA (895; 490-7118 pmol/L) than controls (663; 50-1318 pmol/L) (p = 0.025). NT-proBNP decreased significantly 90 days post-ductal closure (597; 154-1858 pmol/L) (p = 0.013). Left atrial and ventricular size decreased significantly within 24 h and at day 90 as did PCWP (day 90 only). NT-proBNP correlated with vertebral heart size (VHS) and indexed left ventricular systolic diameter (iLVIDs); concentrations ≥ 1224 pmol/L distinguished dogs with elevated VHS and iLVIDs.

CONCLUSIONS:

NT-proBNP is elevated in dogs with PDA, decreases following PDA closure and correlates with select radiographic and echocardiographic markers of cardiac remodeling.

• Authors: Crystal D Hariu, Ashley B Saunders, Sonya G Gordon, Bo Norby, Matthew W Miller
• Journal: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology (J Vet Cardiol) Vol. 15 Issue 3 Pg. 197-204 (Sep 2013) ISSN: 1875-0834 [Electronic] Netherlands
• PMID: 23933478 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Animals
• Biomarkers (blood)
• Case-Control Studies
• Dog Diseases (blood, physiopathology, surgery)
• Dogs
• Ductus Arteriosus, Patent (physiopathology, surgery, veterinary)
• Female
• Hemodynamics
• Male
• Natriuretic Peptide, Brain (blood)
• Peptide Fragments (blood)
• Prospective Studies