Fabrication of multifunctional Gd2O3/Au hybrid nanoprobe via a one-step approach for near-infrared fluorescence and magnetic resonance multimodal imaging in vivo.

Abstract

Facile fabrication of multimodal imaging probes is highly desired for bioimaging application due to their integrated advantages of several imaging modalities. Here, we report a simple and one-step mild strategy to fabricate a multifunctional Gd2O3/Au hybrid nanoprobe. Bovine serum albumin (BSA) was used as the template in the biomineralization synthesis. The fabricated BSA-Gd2O3/Au nanoprobe showed excellent chemical stability, intense near-infrared (NIR) fluorescence, and good magnetic resonance imaging (MRI) ability. The multimodal imaging potential of the prepared multifunctional nanoprobe was demonstrated by successful NIR fluorescent and magnetic resonance blood pool imaging. Further modification of BSA-Gd2O3/Au with arginine-glycine-aspartic acid peptide c(RGDyK) (RGD) enabled the nanoprobe for targeted tumor imaging in vivo.

• Authors: Shao-Kai Sun, Lu-Xi Dong, Yang Cao, Hao-Ran Sun, Xiu-Ping Yan
• Journal: Analytical chemistry (Anal Chem) Vol. 85 Issue 17 Pg. 8436-41 (Sep 03 2013) ISSN: 1520-6882 [Electronic] United States
• PMID: 23924153 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• gadolinium oxide
• Gold
• Gadolinium

Topics

• Animals
• Cattle
• Cell Line, Tumor
• Gadolinium (chemistry)
• Gold (chemistry)
• Magnetic Resonance Imaging (methods)
• Metal Nanoparticles (chemistry)
• Mice, Inbred BALB C
• Mice, Nude
• Multimodal Imaging (methods)
• Protein Structure, Secondary
• Spectroscopy, Near-Infrared (methods)
• Xenograft Model Antitumor Assays (methods)