Abstract | CONTEXT: Fine particulate matter (PM) air pollution has been associated with alterations in circulating endothelial progenitor cell ( EPC) levels, which may be one mechanism whereby exposures promote cardiovascular diseases. However, the impact of coarse PM on EPCs is unknown. OBJECTIVE: We aimed to determine the effect of acute exposure to coarse concentrated ambient particles (CAP) on circulating EPC levels. METHODS: Thirty-two adults (25.9 ± 6.6 years) were exposed to coarse CAP (76.2 ± 51.5 μg m(-3)) in a rural location and filtered air (FA) for 2 h in a randomized double-blind crossover study. Peripheral venous blood was collected 2 and 20 h post-exposures for circulating EPC (n = 21), white blood cell (n = 24) and vascular endothelial growth factor ( VEGF) (n = 16-19) levels. The changes between exposures were compared by matched Wilcoxon signed-rank tests. RESULTS: Circulating EPC levels were elevated 2 [108.29 (6.24-249.71) EPC mL(-1); median (25th-75th percentiles), p = 0.052] and 20 h [106.86 (52.91-278.35) EPC mL(-1), p = 0.008] post-CAP exposure compared to the same time points following FA [38.47 (0.00-84.83) and 50.16 (0.00-104.79) EPC mL(-1)]. VEGF and white blood cell (WBC) levels did not differ between exposures. CONCLUSIONS: Brief inhalation of coarse PM from a rural location elicited an increase in EPCs that persisted for at least 20 h. The underlying mechanism responsible may reflect a systemic reaction to an acute "endothelial injury" and/or a circulating EPC response to sympathetic nervous system activation.
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Authors | Robert D Brook, Robert L Bard, Mariana J Kaplan, Srilakshmi Yalavarthi, Masako Morishita, J Timothy Dvonch, Lu Wang, Hui-Yu Yang, Catherine Spino, Bhramar Mukherjee, Elif A Oral, Qinghua Sun, Jeffrey R Brook, Jack Harkema, Sanjay Rajagopalan |
Journal | Inhalation toxicology
(Inhal Toxicol)
Vol. 25
Issue 10
Pg. 587-92
(Aug 2013)
ISSN: 1091-7691 [Electronic] England |
PMID | 23919441
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Adult
- Cross-Over Studies
- Endothelial Cells
- Female
- Humans
- Male
- Particle Size
- Particulate Matter
(chemistry, toxicity)
- Rural Population
- Stem Cells
- Young Adult
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