Chemopreventive effect of zingerone against colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.

Abstract

Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butane], one of the active phenolic components isolated from Zingiber officinale, has antioxidant and anticarcinogenic properties. In our study, we have evaluated the effect of different doses of zingerone on lipid peroxidation (thiobarbituric acid-reactive substances, lipid hydroxyl radical and conjugated dienes), tissue enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase), and nonenzymatic antioxidants (reduced glutathione, vitamin E, vitamin C), and also the formation of aberrant crypt foci (ACF) in male albino Wistar rats with colon cancer induced using 1,2-dimethylhydrazine (DMH). The rats were divided into six groups. Group 1 served as a control group and received a modified pellet diet; the rats in group 2 received a modified pellet diet along with zingerone (40 mg/kg b.w., orally every day); groups 3-6 were administered DMH (20 mg/kg b.w., subcutaneously) once a week for the first 4 weeks; and groups 4-6 received zingerone at three different doses of 10, 20 and 40 mg/kg b.w., respectively, every day for 16 weeks. Increased tumour incidence and ACF formation were accompanied by a decrease in the tissue lipid peroxidation, enzymatic and nonenzymatic antioxidant activities observed in the colon of DMH-treated rats. Supplementation with zingerone in DMH-treated rats led to a significant decrease in the tumour incidence and ACF formation with simultaneous modulation in the level of tissue lipid peroxidation and antioxidant status. Thus, in conclusion, we can suggest that zingerone effectively inhibits DMH-induced colon carcinogenesis in male Wistar rats.

• Authors: Rajenderan Vinothkumar, Rajamanickam Vinothkumar, Mani Sudha, Namasivayam Nalini
• Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) (Eur J Cancer Prev) Vol. 23 Issue 5 Pg. 361-71 (Sep 2014) ISSN: 1473-5709 [Electronic] England
• PMID: 23903760 (Publication Type: Journal Article)

Chemical References

• Anticarcinogenic Agents
• Antioxidants
• Carcinogens
• zingerone
• Guaiacol
• 1,2-Dimethylhydrazine

Topics

• 1,2-Dimethylhydrazine (toxicity)
• Aberrant Crypt Foci (chemically induced, pathology, prevention & control)
• Animals
• Anticarcinogenic Agents (therapeutic use)
• Antioxidants (metabolism)
• Carcinogenesis (chemically induced, drug effects, pathology)
• Carcinogens (toxicity)
• Colonic Neoplasms (chemically induced, pathology, prevention & control)
• Guaiacol (analogs & derivatives, therapeutic use)
• Lipid Peroxidation (drug effects)
• Male
• Oxidative Stress (drug effects)
• Rats
• Rats, Wistar