Evaluation of the protective effects of CoQ₁₀ on ovarian I/R injury: an experimental study.

Abstract

BACKGROUND:

The aim of this study was to investigate the protective effects of coenzyme Q₁₀ (CoQ₁₀) on ovarian ischemia/reperfusion injury in an experimental rat adnexal torsion model.

METHODS:

48 female adult Wistar albino rats, weighing 220-250 g, were randomly equally divided into six groups (n = 8): sham, torsion, detorsion, sham+CoQ₁₀, torsion+CoQ₁₀, and detorsion+CoQ₁₀ groups. Bilateral adnexal torsion was performed for 3 h in all groups, except the sham and sham+CoQ₁₀ groups. Bilateral adnexal detorsion was performed on the detorsion and detorsion+CoQ₁₀ groups. CoQ₁₀ was injected intraperitoneally 30 min before the sham operation, torsion, and detorsion.

RESULTS:

The torsion and detorsion groups had significantly higher histologic evaluation scores, as well as higher MDA levels, TOS values, and oxidative stress index values than the sham group. A strong correlation between total histologic evaluation scores for ischemia/reperfusion injury and the oxidative stress index was found. The mean oxidant marker levels and histopathologic scores for the ovarian tissue significantly decreased after using CoQ₁₀, which is a potent antioxidant.

CONCLUSIONS:

Conservative surgery (detorsion) was found to provide inadequate protection to ovarian tissue. The results of this study suggest that CoQ₁₀ could be useful for the protection of ovarian tissue before conservative surgery.

• Authors: Ali Ozler, Abdulkadir Turgut, Neval Yaman Görük, Ulas Alabalik, Mustafa Kemal Basarali, Fatih Akdemir
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 76 Issue 2 Pg. 100-6 ( 2013) ISSN: 1423-002X [Electronic] Switzerland
• PMID: 23886769 (Publication Type: Journal Article)
• Copyright: © 2013 S. Karger AG, Basel.

Chemical References

• Ubiquinone
• Malondialdehyde
• Pon1 protein, rat
• Aryldialkylphosphatase
• coenzyme Q10

Topics

• Animals
• Aryldialkylphosphatase (metabolism)
• Female
• Malondialdehyde (metabolism)
• Ovary (blood supply)
• Oxidative Stress
• Rats
• Rats, Wistar
• Reperfusion Injury (etiology, pathology, prevention & control)
• Torsion Abnormality (complications, surgery)
• Ubiquinone (analogs & derivatives, therapeutic use)