Abstract | BACKGROUND: The aim of this study was to compare three different methods to cover excised burn wounds in a randomized controlled trial. METHODS: Fascially excised burn wounds, measuring 10 cm × 5 cm, were covered with Integra(®), split thickness skin graft (STSG), and a viscose cellulose sponge Cellonex™ in each of ten adult patients. Integra(®) and Cellonex™ treated areas were covered with thin STSG on day 14. Biopsies were taken 3, 7, 14, and 21 days, 3 months, and 12 months after surgery, and samples were subjected to a range of immunohistochemical stains, in addition to hematoxylin and eosin (HE). Scar assessment was performed 3 and 12 months post-operatively with the Vancouver Scar Scale (VSS). RESULTS:
Inflammation was not substantial in any of the study areas, but Cellonex™ had the most neutrophils, histiocytes, and lymphocytes with significant differences on days 7 and 14. Complete vascularization of Integra(®) seemed to occur later compared to the other materials. STSG had the most myofibroblasts on day 14 (p = 0.012). In VSS the quality of the scar improved in all materials from 3 to 12 months. CONCLUSIONS: The final results for all treatments after 12 months demonstrate equal clinical appearance, as well as histological and immunohistochemical findings.
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Authors | Heli Lagus, Maarit Sarlomo-Rikala, Tom Böhling, Jyrki Vuola |
Journal | Burns : journal of the International Society for Burn Injuries
(Burns)
Vol. 39
Issue 8
Pg. 1577-87
(Dec 2013)
ISSN: 1879-1409 [Electronic] Netherlands |
PMID | 23880091
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ltd and ISBI. All rights reserved. |
Chemical References |
- Biocompatible Materials
- integra artificial skin
- Cellulose
- Chondroitin Sulfates
- Collagen
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Topics |
- Adult
- Biocompatible Materials
(therapeutic use)
- Burns
(pathology, surgery, therapy)
- Cellulose
(therapeutic use)
- Chondroitin Sulfates
(therapeutic use)
- Collagen
(therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Neovascularization, Physiologic
- Prospective Studies
- Skin Transplantation
(methods)
- Surgical Sponges
- Young Adult
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