Double-blind trials of clemastine ('Tavegil') in allergic rhinitis.

Abstract

Two double-blind randomised trials are reported comparing the effectiveness of the antihistamines, clemastine and chlorpheniramine in comparable doses, in relieving the symptoms of allergic rhinitis. In the first trial, treating 58 adults seen in a general practice, both drugs were prescribed in tablet form; l mg. clemastine b.d. and 4 mg. chlorpheniramine b.d. The second trial was carried out in 42 patients attending a children's E.N.T. out-patient department and the drugs were prescribed as clemastine elixir (0.5 mg. b.d.) or as chlorpheniramine syrup (2 mg. b.d.). Both drugs were effective in providing symptomatic relief in a significant number of patients, and the overall efficacy of clemastine was marginally better than that of chlorpheniramine, especially in the second trial in children. Side-effects were minimal and drowsiness was not a problem.

• Authors: G Todd, P Hopkins, W P Maclay
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 3 Issue 3 Pg. 126-31 ( 1975) ISSN: 0300-7995 [Print] England
• PMID: 238790 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Histamine H1 Antagonists
• Pyrrolidines
• Tablets
• Chlorpheniramine

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Chlorpheniramine (therapeutic use)
• Clinical Trials as Topic
• Drug Evaluation
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Middle Aged
• Pyrrolidines (administration & dosage, adverse effects, therapeutic use)
• Rhinitis, Allergic, Seasonal (drug therapy)
• Tablets