Evaluation of the cerebrospinal fluid amyloid-β1-42/amyloid-β1-40 ratio measured by alpha-LISA to distinguish Alzheimer's disease from other dementia disorders.

Abstract

BACKGROUND:

The well-established core biomarkers used to identify Alzheimer's disease (AD) overlap with other dementia disorders such as dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD). This study aimed to evaluate whether the cerebrospinal fluid (CSF) amyloid-β (Aβ)1-42/Aβ1-40 ratio, measured by a novel method, could improve the differential diagnosis of AD, DLB and PDD.

METHOD:

CSF levels of Aβ1-40 and Aβ1-42 in patients with PDD, DLB, AD, Parkinson's disease and controls were analyzed using an amplified luminescent proximity homogenous immunoassay along with conventional immunoassays.

RESULTS:

The CSF Aβ1-42/Aβ1-40 ratio increased discrimination of AD from PDD and DLB compared with either of the two Aβ biomarkers individually.

CONCLUSION:

The use of the Aβ1-42/Aβ1-40 ratio could improve the differentiation of AD from PDD and DLB.

• Authors: Magdalena Nutu, Henrik Zetterberg, Elisabet Londos, Lennart Minthon, Katarina Nägga, Kaj Blennow, Oskar Hansson, Annika Ohrfelt
• Journal: Dementia and geriatric cognitive disorders (Dement Geriatr Cogn Disord) Vol. 36 Issue 1-2 Pg. 99-110 ( 2013) ISSN: 1421-9824 [Electronic] Switzerland
• PMID: 23860354 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 S. Karger AG, Basel.

Chemical References

• Amyloid beta-Peptides
• Antibodies
• Biomarkers
• Peptide Fragments
• amyloid beta-protein (1-40)
• amyloid beta-protein (1-42)

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (cerebrospinal fluid)
• Amyloid beta-Peptides (cerebrospinal fluid, immunology)
• Antibodies (immunology)
• Area Under Curve
• Biomarkers (cerebrospinal fluid)
• Dementia (cerebrospinal fluid)
• Diagnosis, Differential
• Diagnostic and Statistical Manual of Mental Disorders
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunoassay (methods)
• Lewy Body Disease (cerebrospinal fluid)
• Male
• Middle Aged
• Parkinson Disease (cerebrospinal fluid)
• Peptide Fragments (cerebrospinal fluid, immunology)
• Psychiatric Status Rating Scales