Male overactive bladder: pharmacotherapy for the male.

Abstract

PURPOSE OF REVIEW:

To summarize data concerning the medical treatment of men with overactive bladder symptoms published in peer-reviewed journals between January 2012 and March 2013.

RECENT FINDINGS:

Results of large, randomized trials of solifenacin in combination with tamsulosin in men with lower urinary tract symptoms, including voiding and storage ones, have dominated the medical literature on the subject for the past 12-16 months. Solifenacin in upfront combination with alpha-blockers or as add-on therapy in men with residual storage symptoms despite alpha-blockade offers additional benefits in symptom control. In accordance with data from previous studies on other antimuscarinics, improvements are significant only for some of the efficacy outcomes. Solifenacin in combination with alpha-blockers is associated with an increase in postvoid residual urine volume but not a significantly increased risk of retention. Recent data also indicate that the combination of antimuscarinics with alpha-blockers is cost-effective with long-term efficacy and safety.

SUMMARY:

Recent evidence further supports the efficacy and safety of antimuscarinics in combination with alpha-blockers in treating storage symptoms in men with lower urinary tract symptoms. More studies are needed to evaluate criteria for selecting men likely to benefit more from antimuscarinics and investigate other overactive bladder treatments in male populations.

• Authors: Konstantinos Giannitsas, Anastasios Athanasopoulos
• Journal: Current opinion in urology (Curr Opin Urol) Vol. 23 Issue 6 Pg. 515-9 (Nov 2013) ISSN: 1473-6586 [Electronic] United States
• PMID: 23851386 (Publication Type: Journal Article, Review)

Chemical References

• Adrenergic alpha-Antagonists
• Muscarinic Antagonists

Topics

• Adrenergic alpha-Antagonists (therapeutic use)
• Disease Management
• Drug Therapy (trends)
• Humans
• Lower Urinary Tract Symptoms (drug therapy)
• Male
• Male Urogenital Diseases (drug therapy)
• Muscarinic Antagonists (therapeutic use)
• Treatment Outcome
• Urinary Bladder, Overactive (drug therapy)