Angiotensin receptor blocker (ARB)-diuretic versus ARB-calcium channel blocker combination therapy for hypertension uncontrolled by ARB monotherapy.

Abstract

Diuretics or calcium channel blockers (CCBs) are used concomitantly with an angiotensin II receptor blocker (ARB). However, it is not established which ARB-based combination therapy is the most effective and safe. This prospective randomized open-label study compared the efficacy and safety of a fixed-dose tablet of losartan (LST)-hydrochlorothiazide (HCTZ) (n = 99) and LST-amlodipine (AML) (n = 77) in Japanese patients whose hypertension was uncontrolled by ARB monotherapy. Blood pressure changed similarly over the 12-month study period. Only LST-HCTZ significantly increased serum uric acid (SUA) in patients with low baseline SUA (<5.6 mg/dL) but not in patients with high baseline SUA.

• Authors: Jin Oshikawa, Yoshiyuki Toya, Satoshi Morita, Masataka Taguri, Kazushige Hanaoka, Toshio Hasegawa, Kazo Kaizu, Kouju Kamata, Shuzo Kobayashi, Takayasu Ohtake, Takeo Sato, Gen Yasuda, Kenjiro Kimura, Satoshi Umemura
• Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) (Clin Exp Hypertens) Vol. 36 Issue 4 Pg. 244-50 ( 2014) ISSN: 1525-6006 [Electronic] England
• PMID: 23848219 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin II Type 1 Receptor Blockers
• Calcium Channel Blockers
• Diuretics
• Hydrochlorothiazide
• Uric Acid
• Losartan

Topics

• Adult
• Aged
• Angiotensin II Type 1 Receptor Blockers (administration & dosage)
• Blood Pressure (drug effects)
• Calcium Channel Blockers (administration & dosage)
• Diuretics (administration & dosage)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Humans
• Hydrochlorothiazide (administration & dosage)
• Hypertension (blood, drug therapy, physiopathology)
• Losartan (administration & dosage)
• Male
• Middle Aged
• Prospective Studies
• Time Factors
• Treatment Outcome
• Uric Acid (blood)
• Young Adult