Abstract | BACKGROUND: Antimicrobial resistance has been increasing for several years and is often higher in intensive care units (ICUs) than in other facilities. The spread of extended-spectrum β-lactamases (ESBLs) in particular has profoundly impacted antimicrobial efficacy and usage. The Study for Monitoring Antimicrobial Resistance Trends has monitored the in vitro activity of ertapenem and several comparators against aerobic gram-negative bacteria from intra-abdominal infections (IAIs) for many years. This report summarizes susceptibility levels and epidemiology for key IAI pathogens cultured from general pediatric medical wards and pediatric ICUs globally. METHODS: 1248 gram-negative bacteria were collected from pediatric IAIs by 113 labs in 40 countries from 2008 to 2010. Susceptibility was determined by Clinical and Laboratory Standards Institute broth microdilution. Susceptibility rates (%S) were determined for species with ≥10 isolates. RESULTS: Sixty-two percent of isolates came from general pediatric wards and 38% from pediatric ICUs. The overall ESBL-positive rate was 11.0% for Escherichia coli and 38.9% for Klebsiella pneumoniae; the ESBL-positive rate for E. coli was twice as high in ICU as non-ICU. Most study drugs inhibited >90% of ESBL-negative isolates, but only the carbapenems inhibited >90% of ESBL-positive E. coli and only imipenem inhibited >90% of ESBL-positive K. pneumoniae. CONCLUSIONS:
|
Authors | Robert E Badal, Samuel K Bouchillon, Sibylle H Lob, Meredith A Hackel, Stephen P Hawser, Daryl J Hoban |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 32
Issue 6
Pg. 636-40
(Jun 2013)
ISSN: 1532-0987 [Electronic] United States |
PMID | 23838732
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Bacterial Agents
- beta-Lactamases
|
Topics |
- Adolescent
- Anti-Bacterial Agents
(pharmacology)
- Child
- Child, Preschool
- Drug Resistance, Bacterial
- Female
- Gram-Negative Bacteria
(classification, drug effects, enzymology, isolation & purification)
- Gram-Negative Bacterial Infections
(epidemiology, microbiology)
- Hospitals, Pediatric
- Humans
- Infant
- Infant, Newborn
- Intensive Care Units, Pediatric
- Intraabdominal Infections
(epidemiology, microbiology)
- Male
- Microbial Sensitivity Tests
- beta-Lactamases
(metabolism)
|