Association of ABO blood group and risk of lung cancer in a multicenter study in Turkey.

Abstract

BACKGROUND:

The ABO blood groups and Rh factor may affect the risk of lung cancer.

MATERIALS AND METHODS:

We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them.

RESULTS:

The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology.

CONCLUSIONS:

In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.

• Authors: Yuksel Urun, Gungor Utkan, Ayten Kayi Cangir, Omur Berna Oksuzoglu, Nuriye Ozdemir, Derya Gokmen Oztuna, Gokhan Kocaman, Hasan Şenol Coşkun, Muhammet Ali Kaplan, Cabir Yuksel, Ahmet Demirkazik, Fikri Icli
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 5 Pg. 2801-3 ( 2013) ISSN: 2476-762X [Electronic] Thailand
• PMID: 23803034 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• ABO Blood-Group System
• Rh-Hr Blood-Group System

Topics

• ABO Blood-Group System (blood)
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Female
• Humans
• Lung Neoplasms (blood, epidemiology)
• Male
• Middle Aged
• Retrospective Studies
• Rh-Hr Blood-Group System (blood)
• Risk Factors
• Turkey (epidemiology)
• Young Adult