Serum vascular adhesion protein-1 level is higher in smokers than non-smokers.

Abstract

BACKGROUND:

Semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) is involved in the pathogenesis of both atherosclerosis and cancer. Because chemical components and metabolites of cigarettes are deaminated by SSAO, the relationship between smoking and serum SSAO/VAP-1 was studied in humans.

METHODS:

A total of 451 non-diabetic and normoalbuminuric Han Chinese subjects were recruited to participate in this study. Smoking history was obtained by using a questionnaire and those who smoked more than 100 cigarettes during a 6-month period were considered smokers. Serum VAP-1 concentration was measured by time-resolved immunofluorometric assay. Age, gender, waist circumference and estimated glomerular filtration rate (GFR) were adjusted in different statistical models.

RESULTS:

Smokers were mainly male (85.7% versus 26.3%) and were more obese than non-smokers (p < 0.05). Subjects with higher serum VAP-1 concentrations were older (p < 0.001) and tended to have larger waist circumferences and lower estimated GFR. Serum VAP-1 concentration was higher in smokers than in non-smokers (p < 0.05) after adjusting for age, gender, waist circumference, estimated GFR, liver biochemistry and lipid profile.

CONCLUSIONS:

Cigarette smoking is associated with elevated serum VAP-1 concentration. Whether VAP-1 and its SSAO activity link the relationship between cigarette smoking, atherosclerosis and cancer requires further investigation.

• Authors: Yi-Chia Wang, Hung-Yuan Li, Jung-Nan Wei, Mao-Shin Lin, Shyang-Rong Shih, Cyue-Huei Hua, David J Smith, Jani Vanio, Lee-Ming Chuang
• Journal: Annals of human biology (Ann Hum Biol) 2013 Sep-Oct Vol. 40 Issue 5 Pg. 413-8 ISSN: 1464-5033 [Electronic] England
• PMID: 23802578 (Publication Type: Journal Article)

Chemical References

• Cell Adhesion Molecules
• AOC3 protein, human
• Amine Oxidase (Copper-Containing)

Topics

• Adult
• Aged
• Aged, 80 and over
• Amine Oxidase (Copper-Containing) (blood, metabolism)
• Atherosclerosis (chemically induced, epidemiology)
• Cell Adhesion Molecules (metabolism)
• Cross-Sectional Studies
• Female
• Fluoroimmunoassay
• Humans
• Male
• Middle Aged
• Neoplasms (chemically induced, epidemiology)
• Smoking (adverse effects, epidemiology)
• Taiwan (epidemiology)
• Young Adult