Clinical investigation of fasudil for the prevention of cerebral vasospasm in extracranial carotid artery stenting.

Abstract

To evaluate fasudil hydrochloride for the prevention of cerebral vasospasm (CVS) in extra-cranial carotid angioplasty and stenting (CAS). We retrospectively analyzed 178 patients with unilateral CAS who were given intravenous fasudil hydrochloride during the perioperative period. CVS, hypotension, stroke, and mortality incidence rates were recorded. Of the cohort studied, 80.9 % patients exhibited no local CVS, asymptomatic vasospasm was observed in 17.4 % patients and symptomatic vasospasm in 1.7 % patients via DSA imaging. All CVS was relieved and symptoms disappeared after intra-arterial infusion of papaverine hydrochloride. Intracerebral hemorrhage occurred in two cases during the perioperative period, one of which resulted in death. CVS is a severe complication of CAS. Fasudil hydrochloride can rapidly relieve cerebral vasospasm, has no selective effect on cerebral vasculature, and little influence on blood pressure. It is suitable for the prevention of CVS during interventional treatment of ischemic cerebrovascular disease.

• Authors: Juan Liu, Guo-en Yao, Hua-dong Zhou, Xiao-jiang Jiang, Peng Xie
• Journal: Cell biochemistry and biophysics (Cell Biochem Biophys) Vol. 68 Issue 1 Pg. 185-8 (Jan 2014) ISSN: 1559-0283 [Electronic] United States
• PMID: 23801155 (Publication Type: Journal Article)

Chemical References

• Calcium Channel Blockers
• 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
• fasudil

Topics

• 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine (adverse effects, analogs & derivatives, therapeutic use)
• Aged
• Calcium Channel Blockers (adverse effects, therapeutic use)
• Carotid Arteries
• Cerebral Hemorrhage (etiology)
• Cohort Studies
• Drug-Eluting Stents
• Female
• Humans
• Male
• Middle Aged
• Perioperative Care
• Radiography
• Retrospective Studies
• Vasospasm, Intracranial (diagnostic imaging, pathology, prevention & control)