[Dynamics of the development of oval cell population induced in the liver by dipin and partial hepatectomy].

Abstract

It has been shown that dipin in combination with partial hepatectomy (model of dipin hepato-carcinogenesis) induces massive oval cell proliferation. The main stages of oval cells development examined by means of light microscopy of half-thin slices are the following: 1) appearance around portal tracts--1-3 weeks; 2) migration into parenchyma along terminal branches of portal vessels--3-8 weeks; 3) maximum development--8-10 weeks; 4) induction focuses of growth of new formed hepatocytes around portal tracts--8-10 weeks; 5) forcing of oval cells towards the centre of liver lobules and their elimination. There was close correlation between oval cells development, fibrosis and inflammation. Oval cells remained around portal tracts until the development of numerous hepatomas in 10 months after treatment.

• Authors: S A Radaeva (Pronina), V M Faktor
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 109 Issue 5 Pg. 514-7 (May 1990) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Dinamika razvitiia populiatsii oval'nykh kletok, indutsirovannykh v pecheni myshi dipinom i chastichnoĭ gepatektomieĭ.
• PMID: 2378977 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Alkylating Agents
• Antineoplastic Agents
• Aziridines
• Mutagens
• dipin

Topics

• Alkylating Agents
• Animals
• Antineoplastic Agents
• Aziridines
• Hepatectomy
• Liver (pathology)
• Liver Neoplasms, Experimental (chemically induced, etiology, pathology)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Mutagens
• Time Factors