Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin involvement: a case report and review of literature.

Abstract

No standard treatment has been established in childhood blastic plasmacytoid dendritic cell neoplasma (BPDCN) because of its rarity. We treated with acute lymphoblastic leukemia-type regimen for a child with BPDCN with skin and leukemic involvement. She has been disease-free for 4 years after allogeneic bone marrow transplantation in first complete remission. In 33 cases of pediatric BPDCN, the over survival was significantly lower in the patients with skin manifestation than those without cutaneous involvement. Accordingly, it is important to determine whether allogeneic hematopoietic stem cell transplantation should be applied to first complete remission in the patients with poor prognosis.

• Authors: Kazuo Sakashita, Shoji Saito, Ryu Yanagisawa, Miyuki Tanaka, Kentaro Yoshikawa, Koichi Hirabayashi, Keiko Tsukahara, Mitsuo Motobayashi, Yozo Nakazawa, Kenichi Koike
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 60 Issue 11 Pg. E140-2 (Nov 2013) ISSN: 1545-5017 [Electronic] United States
• PMID: 23788509 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Copyright © 2013 Wiley Periodicals, Inc.

Topics

• Child, Preschool
• Dendritic Cells (pathology)
• Female
• Hematologic Neoplasms (pathology, therapy)
• Hematopoietic Stem Cell Transplantation
• Humans
• Skin Neoplasms (pathology, therapy)
• Transplantation, Homologous