Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus.

Abstract	Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce virus from DNA infections in immunocompromised mice. In these early studies, we have demonstrated both primary and secondary infections, expanded tissue tropism, and extensive dysplasia.
Authors	Nancy M Cladel, Lynn R Budgeon, Timothy K Cooper, Karla K Balogh, Jiafen Hu, Neil D Christensen
Journal	Journal of virology (J Virol) Vol. 87 Issue 16 Pg. 9391-5 (Aug 2013) ISSN: 1098-5514 [Electronic] United States
PMID	23785210 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	DNA, Viral
Topics	Animals Cell Transformation, Neoplastic DNA, Viral (genetics) Disease Models, Animal Female Histocytochemistry Immunocompromised Host Mice Mice, Nude Neck (pathology, virology) Papillomaviridae (genetics, pathogenicity, physiology) Papillomavirus Infections (pathology, virology) Skin (pathology, virology) Transduction, Genetic Transformation, Genetic Vagina (pathology, virology) Viral Tropism Vulva (pathology, virology)

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