Amelioration of hypoglycemia in a patient with malignant insulinoma during the development of the ectopic ACTH syndrome.

Abstract

A patient with functioning islet cell carcinoma is described who had amelioration of her hypoglycemia during the development of ectopic ACTH syndrome. Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome. At autopsy, she was found to have active tuberculosis. Prophylactic antituberculous therapy should be given to high-risk patients with the ectopic ACTH syndrome. High doses of ACTH may be palliative in refractory hypoglycemic states.

• Authors: L Sadoff, J Gordon, S Goldman
• Journal: Diabetes (Diabetes) Vol. 24 Issue 6 Pg. 600-3 (Jun 1975) ISSN: 0012-1797 [Print] United States
• PMID: 237800 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bicarbonates
• Insulin
• Adrenocorticotropic Hormone
• Potassium
• Hydrocortisone

Topics

• Adenoma, Islet Cell (pathology)
• Adrenocorticotropic Hormone (blood, metabolism, therapeutic use)
• Bicarbonates (blood)
• Diabetes Mellitus (etiology)
• Face
• Female
• Humans
• Hydrocortisone (blood)
• Hydrogen-Ion Concentration
• Hypoglycemia (complications, drug therapy)
• Insulin (blood)
• Middle Aged
• Paraneoplastic Endocrine Syndromes (pathology)
• Potassium (blood)
• Tuberculosis, Pleural (pathology)
• Urine