MicroRNAs in the pathogenesis of systemic lupus erythematosus.

Abstract

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease, characterized by the production of autoantibodies against multiple organs. MicroRNAs (miRNAs) are non-coding, single-stranded small RNAs that post-transcriptionally regulate gene expression. Evidence is accumulating that miRNAs play a pivotal role in the pathogenesis of SLE. This article reviews the pertinent publications (searched from the PubMed database) involving the mechanisms of actions of miRNA associated with the pathogenesis of SLE. The search of related literature was extended as far back as 1979. In this mini-review we first introduce the miRNAs briefly and later discuss their regulatory roles in the DNA methylation pathway, type I interferon pathway, estrogen and regulatory T-cells in the pathogenesis of SLE.

• Authors: Xiaochun Ma, Qiji Liu
• Journal: International journal of rheumatic diseases (Int J Rheum Dis) Vol. 16 Issue 2 Pg. 115-21 (Apr 2013) ISSN: 1756-185X [Electronic] England
• PMID: 23773633 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2013 The Authors International Journal of Rheumatic Diseases © 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

Chemical References

• Estrogens
• Inflammation Mediators
• Interferon Type I
• MicroRNAs

Topics

• Animals
• DNA Methylation
• Epigenesis, Genetic
• Estrogens (metabolism)
• Gene Expression Regulation
• Genetic Predisposition to Disease
• Humans
• Inflammation Mediators (metabolism)
• Interferon Type I (metabolism)
• Lupus Erythematosus, Systemic (genetics, immunology, metabolism)
• MicroRNAs (metabolism)
• Prognosis
• Risk Factors
• Signal Transduction
• T-Lymphocytes (immunology, metabolism)